Influenza vaccines contain 2.5 μg of polysorbate 80 per dose. It is also used as an excipient in some European and Canadian influenza vaccines. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone. Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
The cosmetic grade of polysorbate 80 may have more impurities than the food grade. Polysorbate 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash. This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts. Adding this substance prevents milk proteins from completely coating the fat droplets. Polysorbate 80 is used as an emulsifier in foods, though research suggests it may "profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states."įor example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting. Kotilen-80 - Kotilen is a registered trademark of Kolb AG.Tween 80 – Tween is a registered trademark of Croda Americas, Inc.Montanox 80 – Montanox is a registered trademark of Seppic.Kolliphor PS 80 - Kolliphor is a registered trademark of BASF.The critical micelle concentration of polysorbate 80 in pure water is reported as 0.012 mM. (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl).Polyoxyethylene (80) sorbitan monooleate.
#P 80 emulsion full
The full chemical names for polysorbate 80 are: In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
The hydrophilic groups in this compound are poly ethers also known as polyoxyethylene groups, which are polymers of ethylene oxide. Polysorbate 80 is derived from polyethoxylated sorbitan and oleic acid. This synthetic compound is a viscous, water-soluble yellow liquid. Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
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